SELEUCIA (sē-lū’shĭ-a, Gr. Seleukia). The Seleucia of the NT was founded in 300 b.c. by Seleucus I Nicator, to provide a seaport for Syrian Antioch, which lay some sixteen miles (twenty-seven km.) inland. It lay near the mouth of the Orontes and was a naval base in Roman imperial times. It was the port of departure for Paul and Barnabas on their first journey (Acts.13.4). This city is to be distinguished from the Seleucia on the Tigris founded by the same monarch twelve years earlier.