d.457. Bishop of Edessa from 435, he is best known for the letter he sent in 433 to Bishop Mari(s) in Persia. This reveals that he took a mediating position between Nestorianism and the views of Cyril of Alexandria. He also helped to translate into Syriac the writings of , the Antiochene theologian. Because of supposed Nestorianism, he was deposed by the “ ” of Ephesus in 449. Two years later his orthodoxy was vindicated by the . His epistle to Mari was condemned by Emperor Justinian and the Fifth Synod of Constantinople (553) (see ). Only a Greek translation of the letter has survived; all his other writings are lost.