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d.457. Bishop of Edessa from 435, he is best known for the letter he sent in 433 to Bishop Mari(s) in Persia. This reveals that he took a mediating position between Nestorianism and the views of Cyril of Alexandria. He also helped to translate into Syriac the writings of Theodore of Mopsuestia, the Antiochene theologian. Because of supposed Nestorianism, he was deposed by the “Robber Synod” of Ephesus in 449. Two years later his orthodoxy was vindicated by the Council of Chalcedon. His epistle to Mari was condemned by Emperor Justinian and the Fifth Synod of Constantinople (553) (see Three Chapters Controversy). Only a Greek translation of the letter has survived; all his other writings are lost.