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EYESALVE (Gr. kollourion). A preparation compounded of various ingredients used either by simple application or by reduction to a powder to be smeared on the eye (Rev.3.18). When used figuratively it refers to the restoration of spiritual vision.

EYESALVE (κολλούριον, G3141; variant in many MSS, κολλύριον). The word appears in the context of the address to the church at Laodicea (Rev 3:18). The term is a diminutive of the Gr. kollura, “little cake,” a very common dosage form in the Hel. world. It has been suspected that this particular prescription for the spiritual blindness at Laodicea had some special reference to a product of that place, but such assumptions lack sufficient evidence to be more than speculations.

International Standard Bible Encyclopedia (1915)

(kollourion; collyrium; Re 3:18):

A Phrygian powder mentioned by Galen, for which the medical school of Laodicea seems to have been famous (see Ramsay, The Letters to the Seven Churches of Asia), but the figurative reference is to the restoring of spiritual vision.